Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication.
Identifieur interne : 002A16 ( Main/Exploration ); précédent : 002A15; suivant : 002A17Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication.
Auteurs : Jincun Zhao [États-Unis] ; Ana Falc N ; Haixia Zhou ; Jason Netland ; Luis Enjuanes ; Pilar Pérez Bre A ; Stanley PerlmanSource :
- Journal of virology [ 1098-5514 ] ; 2009.
Descripteurs français
- KwdFr :
- Animaux, Cadres ouverts de lecture, Facteur de transcription STAT-1 (métabolisme), Interféron gamma (pharmacologie), Lignée cellulaire, Protéines virales (métabolisme), Récepteurs viraux (métabolisme), Réplication virale, Souris, Souris transgéniques, Syndrome respiratoire aigu sévère (virologie), Virus du SRAS (métabolisme), Virus du SRAS (pathogénicité), Virus du SRAS (physiologie).
- MESH :
- métabolisme : Facteur de transcription STAT-1, Protéines virales, Récepteurs viraux, Virus du SRAS.
- pathogénicité : Virus du SRAS.
- pharmacologie : Interféron gamma.
- physiologie : Virus du SRAS.
- virologie : Syndrome respiratoire aigu sévère.
- Animaux, Cadres ouverts de lecture, Lignée cellulaire, Réplication virale, Souris, Souris transgéniques.
English descriptors
- KwdEn :
- Animals, Cell Line, Interferon-gamma (pharmacology), Mice, Mice, Transgenic, Open Reading Frames, Receptors, Virus (metabolism), SARS Virus (metabolism), SARS Virus (pathogenicity), SARS Virus (physiology), STAT1 Transcription Factor (metabolism), Severe Acute Respiratory Syndrome (virology), Viral Proteins (metabolism), Virus Replication.
- MESH :
- chemical , metabolism : Receptors, Virus, STAT1 Transcription Factor, Viral Proteins.
- chemical , pharmacology : Interferon-gamma.
- metabolism : SARS Virus.
- pathogenicity : SARS Virus.
- physiology : SARS Virus.
- virology : Severe Acute Respiratory Syndrome.
- Animals, Cell Line, Mice, Mice, Transgenic, Open Reading Frames, Virus Replication.
Abstract
Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes several accessory proteins of unknown function. One of these proteins, protein 6 (p6), which is encoded by ORF6, enhances virus replication when introduced into a heterologous murine coronavirus (mouse hepatitis virus [MHV]) but is not essential for optimal SARS-CoV replication after infection at a relatively high multiplicity of infection (MOI). Here, we reconcile these apparently conflicting results by showing that p6 enhances SARS-CoV replication to nearly the same extent as when expressed in the context of MHV if cells are infected at a low MOI and accelerates disease in mice transgenic for the human SARS-CoV receptor.
DOI: 10.1128/JVI.02371-08
PubMed: 19091867
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001993
- to stream PubMed, to step Curation: 001993
- to stream PubMed, to step Checkpoint: 001784
- to stream Ncbi, to step Merge: 001E17
- to stream Ncbi, to step Curation: 001E17
- to stream Ncbi, to step Checkpoint: 001E17
- to stream Main, to step Merge: 002A61
- to stream Main, to step Curation: 002A16
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication.</title><author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, Iowa 52242</wicri:regionArea><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Falc N, Ana" sort="Falc N, Ana" uniqKey="Falc N A" first="Ana" last="Falc N">Ana Falc N</name></author><author><name sortKey="Zhou, Haixia" sort="Zhou, Haixia" uniqKey="Zhou H" first="Haixia" last="Zhou">Haixia Zhou</name></author><author><name sortKey="Netland, Jason" sort="Netland, Jason" uniqKey="Netland J" first="Jason" last="Netland">Jason Netland</name></author><author><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name></author><author><name sortKey="Perez Bre A, Pilar" sort="Perez Bre A, Pilar" uniqKey="Perez Bre A P" first="Pilar" last="Pérez Bre A">Pilar Pérez Bre A</name></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2009">2009</date><idno type="RBID">pubmed:19091867</idno><idno type="pmid">19091867</idno><idno type="doi">10.1128/JVI.02371-08</idno><idno type="wicri:Area/PubMed/Corpus">001993</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001993</idno><idno type="wicri:Area/PubMed/Curation">001993</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001993</idno><idno type="wicri:Area/PubMed/Checkpoint">001784</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001784</idno><idno type="wicri:Area/Ncbi/Merge">001E17</idno><idno type="wicri:Area/Ncbi/Curation">001E17</idno><idno type="wicri:Area/Ncbi/Checkpoint">001E17</idno><idno type="wicri:Area/Main/Merge">002A61</idno><idno type="wicri:Area/Main/Curation">002A16</idno><idno type="wicri:Area/Main/Exploration">002A16</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication.</title><author><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name><affiliation wicri:level="4"><nlm:affiliation>Department of Microbiology, University of Iowa, Iowa City, Iowa 52242, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology, University of Iowa, Iowa City, Iowa 52242</wicri:regionArea><orgName type="university">Université de l'Iowa</orgName><placeName><settlement type="city">Iowa City</settlement><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Falc N, Ana" sort="Falc N, Ana" uniqKey="Falc N A" first="Ana" last="Falc N">Ana Falc N</name></author><author><name sortKey="Zhou, Haixia" sort="Zhou, Haixia" uniqKey="Zhou H" first="Haixia" last="Zhou">Haixia Zhou</name></author><author><name sortKey="Netland, Jason" sort="Netland, Jason" uniqKey="Netland J" first="Jason" last="Netland">Jason Netland</name></author><author><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name></author><author><name sortKey="Perez Bre A, Pilar" sort="Perez Bre A, Pilar" uniqKey="Perez Bre A P" first="Pilar" last="Pérez Bre A">Pilar Pérez Bre A</name></author><author><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name></author></analytic><series><title level="j">Journal of virology</title><idno type="eISSN">1098-5514</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Interferon-gamma (pharmacology)</term><term>Mice</term><term>Mice, Transgenic</term><term>Open Reading Frames</term><term>Receptors, Virus (metabolism)</term><term>SARS Virus (metabolism)</term><term>SARS Virus (pathogenicity)</term><term>SARS Virus (physiology)</term><term>STAT1 Transcription Factor (metabolism)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Viral Proteins (metabolism)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Facteur de transcription STAT-1 (métabolisme)</term><term>Interféron gamma (pharmacologie)</term><term>Lignée cellulaire</term><term>Protéines virales (métabolisme)</term><term>Récepteurs viraux (métabolisme)</term><term>Réplication virale</term><term>Souris</term><term>Souris transgéniques</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Virus du SRAS (métabolisme)</term><term>Virus du SRAS (pathogénicité)</term><term>Virus du SRAS (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Virus</term><term>STAT1 Transcription Factor</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Interferon-gamma</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteur de transcription STAT-1</term><term>Protéines virales</term><term>Récepteurs viraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Interféron gamma</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Mice</term><term>Mice, Transgenic</term><term>Open Reading Frames</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cadres ouverts de lecture</term><term>Lignée cellulaire</term><term>Réplication virale</term><term>Souris</term><term>Souris transgéniques</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Severe acute respiratory syndrome coronavirus (SARS-CoV) encodes several accessory proteins of unknown function. One of these proteins, protein 6 (p6), which is encoded by ORF6, enhances virus replication when introduced into a heterologous murine coronavirus (mouse hepatitis virus [MHV]) but is not essential for optimal SARS-CoV replication after infection at a relatively high multiplicity of infection (MOI). Here, we reconcile these apparently conflicting results by showing that p6 enhances SARS-CoV replication to nearly the same extent as when expressed in the context of MHV if cells are infected at a low MOI and accelerates disease in mice transgenic for the human SARS-CoV receptor.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li></region><settlement><li>Iowa City</li></settlement><orgName><li>Université de l'Iowa</li></orgName></list><tree><noCountry><name sortKey="Enjuanes, Luis" sort="Enjuanes, Luis" uniqKey="Enjuanes L" first="Luis" last="Enjuanes">Luis Enjuanes</name><name sortKey="Falc N, Ana" sort="Falc N, Ana" uniqKey="Falc N A" first="Ana" last="Falc N">Ana Falc N</name><name sortKey="Netland, Jason" sort="Netland, Jason" uniqKey="Netland J" first="Jason" last="Netland">Jason Netland</name><name sortKey="Perez Bre A, Pilar" sort="Perez Bre A, Pilar" uniqKey="Perez Bre A P" first="Pilar" last="Pérez Bre A">Pilar Pérez Bre A</name><name sortKey="Perlman, Stanley" sort="Perlman, Stanley" uniqKey="Perlman S" first="Stanley" last="Perlman">Stanley Perlman</name><name sortKey="Zhou, Haixia" sort="Zhou, Haixia" uniqKey="Zhou H" first="Haixia" last="Zhou">Haixia Zhou</name></noCountry><country name="États-Unis"><region name="Iowa"><name sortKey="Zhao, Jincun" sort="Zhao, Jincun" uniqKey="Zhao J" first="Jincun" last="Zhao">Jincun Zhao</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002A16 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002A16 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:19091867
|texte= Severe acute respiratory syndrome coronavirus protein 6 is required for optimal replication.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:19091867" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |